Showing posts with label Prostate Cancer. Show all posts
Showing posts with label Prostate Cancer. Show all posts

Wednesday, 21 January 2015

A Wee Problem That’s More Common Than You Think

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Prostate symptoms are extremely usual in males over the age of 50, yet many are putting off seeing their doctor about it. 
Men are notorious for burying their heads in the sand about their health, and it seems this is especially true when it comes to things going on ‘down there’ potentially relating to the prostate, the gland which sits underneath men’s bladders, surrounds the urethra and produces semen.
One in five UK men would turn a blind eye to prostate problems, according to a recent survey by herbal brand A.Vogel. In fact, 20% admitted that if they experienced symptoms like needing to pee more frequently or urgently, feeling that they’re unable to fully empty their bladder, or difficulty urinating, they would “just ignore it and hope it got better by itself”.
“It can be tough for men talking about their health in general, let alone when it relates to something so sensitive,” says GP Dr Roger Henderson. “In my experience, there are three main reasons men delay coming forward: embarrassment, fear that it may be cancer, or the belief that it’s just a natural part of ageing and there’s nothing they can do.”
Hashim Ahmed, a consultant urologist at the Bupa Cromwell Hospital , understands the complexity of cancer worries. As well as the fear of being diagnosed, the tests involved can be daunting, as can the prospect of treatment and potential side-effects; impotence and incontinence are often big concerns.
“Men are concerned about what might happen if they did go and get a check of their prostate, things like worrying about a back passage examination, and the subsequent tests that can sometimes involve biopsies.
“And then there’s been a lot of press about the fact that prostate cancer treatment itself is quite controversial,” he explains, referring to how many experts believe that aggressive treatment for early prostate cancer actually offers very little benefit, so may lead to unnecessary distress and side-effects, and the fact that traditional testing methods have been highlighted as being potentially unreliable.
“All of these things have contributed to quite a lot of confusion in the public eye,” Ahmed notes.
CANCER CONCERNS
This fear and confusion means two things. Firstly, men who do have cancer may be delaying their diagnosis, and secondly, that men whose symptoms are due to benign conditions may be missing out on treatments.
Though prostate cancer is the most common cancer in UK males, it is still relatively rare, affecting around one in eight men, with most diagnosed between the ages of 70-74.
As Ahmed points out though, as with all cancers, early diagnosis is absolutely crucial. And testing methods have come a long way in the last five years, which means more accurate diagnoses can be made and not all men will require the most aggressive forms of treatment. Side-effects are not always inevitable, either.
A COMMON PROBLEM
The vast majority who experience symptoms, however, will not have cancer. These symptoms are extremely common as men get older, and are most often caused by an enlarged prostate, known medically as benign prostatic hyperplasia (BPH), which affects 50% of men over 50. Despite that, the A.Vogel survey also revealed that nearly 70% had never heard of the condition.
“It’s linked with an increase in the size of the prostate gland, due to an increase in cells,” explains Dr Henderson, who has helped launch A.Vogel’s ‘Enlarged Prostate Health Hub’ 
“BPH is associated with a number of common symptoms, including a need to pass water more frequently and urgently, often at night, with occasional leaking or dribbling, hesitancy in passing water, or a weak stream of straining, and a feeling that the bladder is never fully empty.”
Age is the major risk factor, he points out, though a family history can also play a role, and having high blood pressure or diabetes may also be linked with an increased risk.
Also, men with a history of BPH are not at higher risk of developing cancer. “This is a common misconception,” says Henderson. “Although there can be similarities in the nature of the symptoms, having BPH does not increase your risk of prostate cancer in any way.”
READY RELIEF
“BPH can have a significant effect on quality of life,” Henderson notes, “affecting sleep, work, relationships and sex. If left untreated, it can result in complications, such as bladder infections, acute or chronic urine retention, which can affect kidneys, and hernia from straining.”
The good news is though, that BPH is most often easily treatable. Some men with mild symptoms may choose to take a “wait and watch” approach, or make some lifestyle changes. “Things such as cutting down on caffeine and alcohol, especially late at night, as these can make you need the toilet more, and stopping smoking, as nicotine can irritate the bladder,” 
Ahmed notes that an antioxidant-rich diet, particularly containing things like pomegranate juice, cooked tomatoes, broccoli and green tea, could help promote good prostate health.
When symptoms are more severe and are impacting a man’s quality of life, tablets can be prescribed which, usually, are very effective.
Sometimes, though rarely, further treatments, such as laser treatment, may be needed.
OTHER CAUSES
Though benign growths or enlargement are the most common cause of prostate symptoms, sometimes other conditions come into play. “The other thing that can occur, particularly in younger men who have these symptoms whose prostates are quite small, is that the prostate can become quite tight, so the muscle cells, for some reason, tighten up all the time,” notes Ahmed. “Again, that can be treated with tablets to relax the prostate and neck of the bladder, to enable urine to pass better.
“Also, you could have an infection, and that would be detected with a simple urine test and easily treated with antibiotics. And very rarely, men can have a narrowing in the wall of the urine passage from scar tissue, but that’s unusual.”
In the case of infections – or inflammation without infection – it tends to be younger men who are affected (mainly aged 30-50) and symptoms may be accompanied by pain and discomfort.

Sunday, 31 August 2014

Tomato-rich diet 'reduces prostate cancer risk'

“Tomatoes ‘cut risk of prostate cancer by 20%’,” the Daily Mail reports, citing a study that found men who ate 10 or more portions a week had a reduced risk of the disease.
The study in question gathered a year’s dietary information from 1,806 men who were found to have prostate cancer and 12,005 who were clear after random prostate checks. The researchers compared the diets and adjusted the results to take into account factors such as age, family history of prostate cancer and ethnicity.
They found that men who ate more than 10 portions of tomatoes or tomato products per week have an 18% reduced risk of prostate cancer compared to men who ate less than 10.
As this was a case controlled study, and not a randomised controlled trial, it cannot prove that eating more tomatoes prevents prostate cancer. It can only show an association.
The association is biologically plausible, because tomatoes are a rich source of lycopene, a nutrient thought to protect against cell damage. However, the jury is still out on whether it really does protect cells.
So a healthy, balanced diet, regular exercise and stopping smoking are still the way to go. It’s unlikely that focusing on one particular food will improve your health.
Researchers found that a diet rich in fresh fruits and vegetables had a protective effect

 

 

Where did the story come from?

The study was carried out by researchers from the University of Bristol, the National Institute for Health Research (NIHR) Bristol Nutrition Biomedical Research Unit, Addenbrooke’s Hospital in Cambridge and the University of Oxford. It was funded by the NIHR and Cancer Research UK.
The study was published in the peer-reviewed medical journal Cancer Epidemiology, Biomarkers and Prevention.
In general, the media reported the story accurately but also reported different numbers of study participants, ranging from 1,800 to 20,000. This is because out of the 23,720 men who were initially included in the study, a proportion were excluded from the analyses due to missing questionnaires.
Several news sources have also reported that eating the recommended five portions of fruit or veg per day reduced the risk of prostate cancer by 24% compared to 2.5 servings or less per day. This seems to have come directly from the lead researcher, but these figures are not clearly presented in the research paper.

What kind of research was this?

This was a case-control study looking at the diet, lifestyle and weight of men who had had a prostate check and were subsequently diagnosed with (cases) and without (controls) prostate cancer. The researchers wanted to see if there were any factors that reduced the risk of being diagnosed with prostate cancer.
A previous systematic review suggested that a diet high in calcium is associated with an increased risk of prostate cancer and that diets high in selenium and lycopene are associated with reduced risk. Selenium is a chemical element essential for life that is found in animals and plants, but high levels are toxic. Lycopene is a nutrient found in red foods such as tomatoes and pink grapefruit.
The researchers defined intake of selenium and lycopene as the “prostate cancer dietary index”. They looked at whether there was an association between men’s index scores and their risk of having prostate cancer.
In addition, in 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) made eight recommendations on diet, exercise and weight for cancer prevention. 

The eight cancer prevention recommendations

The eight recommendations drawn up by the WCRF and AICR, some of which are harder to stick to than others, are:
  • be as lean as possible without being underweight
  • stay physically active every day
  • limit consumption of energy-dense foods and avoid sugary drinks
  • the diet should consist of foods mostly from plant origin
  • limit intake of red and processed meat
  • limit consumption of alcoholic drinks
  • limit consumption of salty foods and foods processed with salt
  • don’t take supplements in an attempt to prevent cancer

However, recent research has shown conflicting results as to whether these recommendations are applicable to prostate cancer. One large European study found that men who followed the recommendations did not have a lower general prostate cancer risk, and the other found that men did have a reduced risk of aggressive prostate cancer.

The researchers wanted to see if these recommendations should be changed to include any of the prostate cancer dietary index components for men and/or men at higher risk of prostate cancer.

What did the research involve?


The researchers used data collected from a large UK study called the ProtecT trial. In this trial, 227,300 randomly selected men aged 50 to 69 were invited to have a prostate check between 2001 and 2009.

Nearly half of the men then had a prostate specific antigen (PSA) test and 11% of them went on to have further investigations. Before the test they were asked to fill out questionnaires on:


  • lifestyle

  • diet

  • alcohol intake

  • medical history

  • family history

They were also asked to provide information on their:


  • physical activity level

  • body mass index (BMI)

  • waist circumference

  • body size aged 20, 40 and at the time they entered the study


Statistical analyses were then performed to determine the risk of low or high grade prostate cancer according to adherence to the WCRF/AICR recommendations or intake of any of the three dietary components of the prostate cancer dietary index. The results were adjusted to take into account the following confounders:


  • age

  • family history of prostate cancer

  • self-reported diabetes

  • ethnic group

  • occupational class

  • smoking status

  • total energy intake
  • How did the researchers interpret the results?


    The researchers concluded that, “in addition to meeting the optimal intake for the three dietary factors associated with prostate cancer, men should maintain a healthy weight and an active lifestyle to reduce risk of developing prostate cancer, cardiovascular diseases and diabetes”. They also say that “high intake of plant foods and tomato products in particular may help protect against prostate cancer, which warrants further investigations”.


    Conclusion


    This large study has shown an association between the consumption of more than 10 portions of tomatoes per week and an 18% reduction in risk of prostate cancer. However, as this was a case controlled study, and not a randomised controlled trial, it cannot prove that eating more tomatoes prevents prostate cancer.

    Strengths of the study include its large size and attempts to account for potential confounding factors, although there are some limitations to the study, including:


    • reliance on the accuracy of the dietary questionnaires

    • broad categories for self-estimate of body size

    This study does not provide enough evidence to change the recommendations for reducing the risk of prostate cancer. A healthy, balanced dietregular exercise and stopping smoking are still the way to go, rather than relying on eating one exclusive food type such as tomatoes